Trazodone is a tetracyclic antidepressant used to treat depression and anxiety disorders. Includes trazodone side effects, interactions and indications. Trazodone (Desyrel, Trialodine) is an inexpensive drug used to treat depression. This drug is more popular than comparable drugs. It is available in multiple generic and brand versions. Trazodone is a prescription drug that is used for treating depression in adults. The medication is believed to work by balancing serotonin levels in the brain and blocking certain serotonin receptors. Along with its needed effects, trazodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Trazodone is approved by the FDA as a prescription drug used for the medical treatment of depression. Learn about side effects, drug interactions, dosages, warnings, and more. Find patient medical information for Trazodone Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Description Trazodone acts to change the balance of naturally occurring chemicals in the brain that regulate the transmission of nerve impulses between cells. La trazodone (Desyrel, Trittico, Thombran, Trialodine) est un composé psychoactif sédatif, anxiolytique et antidépresseur. L'effet antidépresseur se manifeste à partir de deux ou trois semaines de traitement alors que l'effet sédatif est sensible après seulement quelques jours [2] Trazodone is an oral antidepressant drug that affects the chemical messengers (neurotransmitters) within the brain that nerves use to communicate with (stimulate) each other. Trazodone is used to treat depression. Trazodone is in a class of medications called serotonin modulators. It works by increasing the amount of serotonin, a natural substance in the brain that helps maintain mental balance.